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Dexmedetomidine hydrochloride
🥰Excellent
Catalog No. T6466Cas No. 145108-58-3
Alias Precedex, Dexmedetomidine HCl, (S)-Medetomidine hydrochloride, (+)-Medetomidine hydrochloride
Dexmedetomidine hydrochloride (Precedex) is a potent, selective, orally active α2-adrenoceptor agonist with a Ki value of 1.08 nM. It shows 1620-fold selectivity over α1-adrenoceptors. Dexmedetomidine hydrochloride (Precedex) can protect against sepsis-induced acute lung injury through anti-inflammatory, anti-oxidative, and anti-apoptotic effects.
Dexmedetomidine hydrochloride
🥰Excellent
Purity: 100.00%
Catalog No. T6466Alias Precedex, Dexmedetomidine HCl, (S)-Medetomidine hydrochloride, (+)-Medetomidine hydrochlorideCas No. 145108-58-3
Dexmedetomidine hydrochloride (Precedex) is a potent, selective, orally active α2-adrenoceptor agonist with a Ki value of 1.08 nM. It shows 1620-fold selectivity over α1-adrenoceptors. Dexmedetomidine hydrochloride (Precedex) can protect against sepsis-induced acute lung injury through anti-inflammatory, anti-oxidative, and anti-apoptotic effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $35 | In Stock | |
| 10 mg | $50 | In Stock | |
| 25 mg | $90 | In Stock | |
| 50 mg | $162 | In Stock | |
| 100 mg | $238 | In Stock | |
| 200 mg | $358 | In Stock | |
| 500 mg | $593 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $46 | In Stock |
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Purity:100.00%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dexmedetomidine hydrochloride (Precedex) is a potent, selective, orally active α2-adrenoceptor agonist with a Ki value of 1.08 nM. It shows 1620-fold selectivity over α1-adrenoceptors. Dexmedetomidine hydrochloride (Precedex) can protect against sepsis-induced acute lung injury through anti-inflammatory, anti-oxidative, and anti-apoptotic effects. |
| Targets&IC50 | α2-adrenoceptor:1.08 nM (IC50) |
| In vitro | METHODS: NR8383 alveolar macrophages were stimulated with 10 μg/ml LPS for 24 hours and then treated with Dexmedetomidine hydrochloride (Precedex) (0.01, 0.1, 1, 10, 50 μM, 2 hours) for another 2 hours. CCK-8 assay was used to evaluate the effect of different concentrations of Dexmedetomidine hydrochloride (Precedex) pretreatment on the viability of LPS-treated NR8383 cells. RESULTS Cell viability gradually increased with increasing concentrations of Dexmedetomidine hydrochloride (Precedex). [1] |
| In vivo | METHODS: Using C57BL/6J mice exposed to LPS, we investigated whether Dexmedetomidine hydrochloride (Precedex) (50 μg/kg, intraperitoneal injection) provides lung protection by regulating mitochondrial dynamics via the HIF-1a/HO-1 pathway in vivo. RESULTS Dexmedetomidine hydrochloride (Precedex) alleviated lung pathological damage, reduced the oxidative stress index (OSI), improved mitochondrial dysfunction, upregulated the expression of HIF-1α and HO-1, and was accompanied by a shift in mitochondrial dynamics to fusion. [1] |
| Kinase Assay | In vitro HDAC assay:HDAC activity is analyzed by using an HDAC assay kit. This assay is based on the ability of DU-145 nuclear extract, which is rich in HDAC activity, to mediate the deacetylation of the biotinylated [3H]-acetyl histone H4 peptide that is bound to streptavidin agarose beads. The release of [3H]-acetate into the supernatant is measured to calculate the HDAC activity. Sodium butyrate (0.25-1 mM) is used as a positive control. |
| Alias | Precedex, Dexmedetomidine HCl, (S)-Medetomidine hydrochloride, (+)-Medetomidine hydrochloride |
| Molecular Weight | 236.74 |
| Formula | C13H16N2·HCl |
| Cas No. | 145108-58-3 |
| Smiles | Cl.C[C@H](c1cnc[nH]1)c1cccc(C)c1C |
| Relative Density. | 1.17 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (232.32 mM)  H2O: 23.7 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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